Überlebenswichtig: Glutaminsynthetasehomologe Proteine in Streptomyceten
نویسندگان
چکیده
Abstract Streptomycetes have to cope with fluctuating nitrogen conditions in soil. Key enzymes metabolism streptomycetes are the two glutamine synthetases (GSs), GlnA and GlnII. We demonstrated that GlnA3 GlnA4, proteins previously annotated as GSs, involved utilization detoxification of polyamines ethanolamine. Homologs these present pathogenic Actinobacteria promising drug targets. designed a novel strategy for development anti-tubercular antibiotics based on inhibition GlnA3.
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ژورنال
عنوان ژورنال: Biospektrum
سال: 2022
ISSN: ['0947-0867', '1868-6249']
DOI: https://doi.org/10.1007/s12268-022-1685-x